Threonine deficiency decreased intestinal immunity and aggravated inflammation associated with NF-κB and target of rapamycin signalling pathways in juvenile grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila.
Identifieur interne : 000705 ( Main/Exploration ); précédent : 000704; suivant : 000706Threonine deficiency decreased intestinal immunity and aggravated inflammation associated with NF-κB and target of rapamycin signalling pathways in juvenile grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila.
Auteurs : Yu-Wen Dong [République populaire de Chine] ; Wei-Dan Jiang [République populaire de Chine] ; Yang Liu [République populaire de Chine] ; Pei Wu [République populaire de Chine] ; Jun Jiang [République populaire de Chine] ; Sheng-Yao Kuang [République populaire de Chine] ; Ling Tang [République populaire de Chine] ; Wu-Neng Tang [République populaire de Chine] ; Yong-An Zhang [République populaire de Chine] ; Xiao-Qiu Zhou [République populaire de Chine] ; Lin Feng [République populaire de Chine]Source :
- The British journal of nutrition [ 1475-2662 ] ; 2017.
Descripteurs français
- KwdFr :
- Aeromonas hydrophila (MeSH), Animaux (MeSH), Carpes (poisson) (immunologie), Carpes (poisson) (microbiologie), Cytokines (génétique), Cytokines (métabolisme), Entérite (médecine vétérinaire), Facteur de transcription NF-kappa B (métabolisme), Hepcidines (MeSH), Immunoglobuline M (MeSH), Infections bactériennes à Gram négatif (médecine vétérinaire), Intestins (enzymologie), Intestins (immunologie), Lysozyme (métabolisme), Maladies des poissons (immunologie), Maladies des poissons (microbiologie), Peptides antimicrobiens cationiques (génétique), Protéines de poisson (génétique), Protéines du sang (MeSH), Régime alimentaire (médecine vétérinaire), Régulation négative (effets des médicaments et des substances chimiques), Régulation positive (effets des médicaments et des substances chimiques), Sérine-thréonine kinases TOR (métabolisme), Thréonine (administration et posologie), Thréonine (déficit), Transduction du signal (physiologie).
- MESH :
- administration et posologie : Thréonine.
- déficit : Thréonine.
- effets des médicaments et des substances chimiques : Régulation négative, Régulation positive.
- enzymologie : Intestins.
- génétique : Cytokines, Peptides antimicrobiens cationiques, Protéines de poisson.
- immunologie : Carpes (poisson), Intestins, Maladies des poissons.
- microbiologie : Carpes (poisson), Maladies des poissons.
- médecine vétérinaire : Entérite, Infections bactériennes à Gram négatif, Régime alimentaire.
- métabolisme : Cytokines, Facteur de transcription NF-kappa B, Lysozyme, Sérine-thréonine kinases TOR.
- physiologie : Transduction du signal.
- Aeromonas hydrophila, Animaux, Hepcidines, Immunoglobuline M, Protéines du sang.
English descriptors
- KwdEn :
- Aeromonas hydrophila (MeSH), Animals (MeSH), Antimicrobial Cationic Peptides (genetics), Blood Proteins (MeSH), Carps (immunology), Carps (microbiology), Cytokines (genetics), Cytokines (metabolism), Diet (veterinary), Down-Regulation (drug effects), Enteritis (veterinary), Fish Diseases (immunology), Fish Diseases (microbiology), Fish Proteins (genetics), Gram-Negative Bacterial Infections (veterinary), Hepcidins (MeSH), Immunoglobulin M (MeSH), Intestines (enzymology), Intestines (immunology), Muramidase (metabolism), NF-kappa B (metabolism), Signal Transduction (physiology), TOR Serine-Threonine Kinases (metabolism), Threonine (administration & dosage), Threonine (deficiency), Up-Regulation (drug effects).
- MESH :
- chemical , administration & dosage : Threonine.
- chemical , deficiency : Threonine.
- chemical , genetics : Antimicrobial Cationic Peptides, Cytokines, Fish Proteins.
- drug effects : Down-Regulation, Up-Regulation.
- enzymology : Intestines.
- immunology : Carps, Fish Diseases, Intestines.
- chemical , metabolism : Cytokines, Muramidase, NF-kappa B, TOR Serine-Threonine Kinases.
- microbiology : Carps, Fish Diseases.
- physiology : Signal Transduction.
- veterinary : Diet, Enteritis, Gram-Negative Bacterial Infections.
- Aeromonas hydrophila, Animals, Blood Proteins, Hepcidins, Immunoglobulin M.
Abstract
This study aimed to investigate the impacts of dietary threonine on intestinal immunity and inflammation in juvenile grass carp. Six iso-nitrogenous semi-purified diets containing graded levels of threonine (3·99-21·66 g threonine/kg) were formulated and fed to fishes for 8 weeks, and then challenged with Aeromonas hydrophila for 14 d. Results showed that, compared with optimum threonine supplementation, threonine deficiency (1) decreased the ability of fish against enteritis, intestinal lysozyme activities (except in the distal intestine), acid phosphatase activities, complement 3 (C3) and C4 contents and IgM contents (except in the proximal intestine (PI)), and it down-regulated the transcript abundances of liver-expressed antimicrobial peptide (LEAP)-2A, LEAP-2B, hepcidin, IgZ, IgM and β-defensin1 (except in the PI) (P<0·05); (2) could up-regulate intestinal pro-inflammatory cytokines TNF-α, IL-1β, IL-6, IL-8 and IL-17D mRNA levels partly related to NF-κB signalling; (3) could down-regulate intestinal anti-inflammatory cytokine transforming growth factor (TGF)-β1, TGF-β2, IL-4/13A (not IL-4/13B) and IL-10 mRNA levels partly by target of rapamycin signalling. Finally, on the basis of the specific growth rate, against the enteritis morbidity and IgM contents, the optimum threonine requirements were estimated to be 14·53 g threonine/kg diet (4·48 g threonine/100 g protein), 15.05 g threonine/kg diet (4·64 g threonine/100 g protein) and 15·17 g threonine/kg diet (4·68 g threonine/100 g protein), respectively.
DOI: 10.1017/S0007114517001830
PubMed: 28820083
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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signalling pathways in juvenile grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila.</title><author><name sortKey="Dong, Yu Wen" sort="Dong, Yu Wen" uniqKey="Dong Y" first="Yu-Wen" last="Dong">Yu-Wen Dong</name><affiliation wicri:level="1"><nlm:affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Wei Dan" sort="Jiang, Wei Dan" uniqKey="Jiang W" first="Wei-Dan" last="Jiang">Wei-Dan Jiang</name><affiliation wicri:level="1"><nlm:affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><affiliation wicri:level="1"><nlm:affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Pei" sort="Wu, Pei" uniqKey="Wu P" first="Pei" last="Wu">Pei Wu</name><affiliation wicri:level="1"><nlm:affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</nlm:affiliation><country 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Science,Chengdu 610066,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Ling" sort="Tang, Ling" uniqKey="Tang L" first="Ling" last="Tang">Ling Tang</name><affiliation wicri:level="1"><nlm:affiliation>4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Wu Neng" sort="Tang, Wu Neng" uniqKey="Tang W" first="Wu-Neng" last="Tang">Wu-Neng Tang</name><affiliation wicri:level="1"><nlm:affiliation>4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066</wicri:regionArea><wicri:noRegion>Chengdu 610066</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Yong An" sort="Zhang, Yong An" uniqKey="Zhang Y" first="Yong-An" last="Zhang">Yong-An Zhang</name><affiliation wicri:level="1"><nlm:affiliation>5Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>5Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Zhou, Xiao Qiu" sort="Zhou, Xiao Qiu" uniqKey="Zhou X" first="Xiao-Qiu" last="Zhou">Xiao-Qiu Zhou</name><affiliation wicri:level="1"><nlm:affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author><author><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><affiliation wicri:level="1"><nlm:affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130</wicri:regionArea><wicri:noRegion>Chengdu 611130</wicri:noRegion></affiliation></author></analytic><series><title level="j">The British journal of nutrition</title><idno type="eISSN">1475-2662</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aeromonas hydrophila (MeSH)</term><term>Animals (MeSH)</term><term>Antimicrobial Cationic Peptides (genetics)</term><term>Blood Proteins (MeSH)</term><term>Carps (immunology)</term><term>Carps (microbiology)</term><term>Cytokines (genetics)</term><term>Cytokines (metabolism)</term><term>Diet (veterinary)</term><term>Down-Regulation (drug effects)</term><term>Enteritis (veterinary)</term><term>Fish Diseases (immunology)</term><term>Fish Diseases (microbiology)</term><term>Fish Proteins (genetics)</term><term>Gram-Negative Bacterial Infections (veterinary)</term><term>Hepcidins (MeSH)</term><term>Immunoglobulin M (MeSH)</term><term>Intestines (enzymology)</term><term>Intestines (immunology)</term><term>Muramidase (metabolism)</term><term>NF-kappa B (metabolism)</term><term>Signal Transduction (physiology)</term><term>TOR Serine-Threonine Kinases (metabolism)</term><term>Threonine (administration & dosage)</term><term>Threonine (deficiency)</term><term>Up-Regulation (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aeromonas hydrophila (MeSH)</term><term>Animaux (MeSH)</term><term>Carpes (poisson) (immunologie)</term><term>Carpes (poisson) (microbiologie)</term><term>Cytokines (génétique)</term><term>Cytokines (métabolisme)</term><term>Entérite (médecine vétérinaire)</term><term>Facteur de transcription NF-kappa B (métabolisme)</term><term>Hepcidines (MeSH)</term><term>Immunoglobuline M (MeSH)</term><term>Infections bactériennes à Gram négatif (médecine vétérinaire)</term><term>Intestins (enzymologie)</term><term>Intestins (immunologie)</term><term>Lysozyme (métabolisme)</term><term>Maladies des poissons (immunologie)</term><term>Maladies des poissons (microbiologie)</term><term>Peptides antimicrobiens cationiques (génétique)</term><term>Protéines de poisson (génétique)</term><term>Protéines du sang (MeSH)</term><term>Régime alimentaire (médecine vétérinaire)</term><term>Régulation négative (effets des médicaments et des substances chimiques)</term><term>Régulation positive (effets des médicaments et des substances chimiques)</term><term>Sérine-thréonine kinases TOR (métabolisme)</term><term>Thréonine (administration et posologie)</term><term>Thréonine (déficit)</term><term>Transduction du signal (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Threonine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Threonine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antimicrobial Cationic Peptides</term><term>Cytokines</term><term>Fish Proteins</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Thréonine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Down-Regulation</term><term>Up-Regulation</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Thréonine</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Régulation négative</term><term>Régulation positive</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Intestins</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Intestines</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytokines</term><term>Peptides antimicrobiens cationiques</term><term>Protéines de poisson</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Carpes (poisson)</term><term>Intestins</term><term>Maladies des poissons</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Carps</term><term>Fish Diseases</term><term>Intestines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Muramidase</term><term>NF-kappa B</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Carpes (poisson)</term><term>Maladies des poissons</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Carps</term><term>Fish Diseases</term></keywords><keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Entérite</term><term>Infections bactériennes à Gram négatif</term><term>Régime alimentaire</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Facteur de transcription NF-kappa B</term><term>Lysozyme</term><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Transduction du signal</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Diet</term><term>Enteritis</term><term>Gram-Negative Bacterial Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aeromonas hydrophila</term><term>Animals</term><term>Blood Proteins</term><term>Hepcidins</term><term>Immunoglobulin M</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Aeromonas hydrophila</term><term>Animaux</term><term>Hepcidines</term><term>Immunoglobuline M</term><term>Protéines du sang</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study aimed to investigate the impacts of dietary threonine on intestinal immunity and inflammation in juvenile grass carp. Six iso-nitrogenous semi-purified diets containing graded levels of threonine (3·99-21·66 g threonine/kg) were formulated and fed to fishes for 8 weeks, and then challenged with Aeromonas hydrophila for 14 d. Results showed that, compared with optimum threonine supplementation, threonine deficiency (1) decreased the ability of fish against enteritis, intestinal lysozyme activities (except in the distal intestine), acid phosphatase activities, complement 3 (C3) and C4 contents and IgM contents (except in the proximal intestine (PI)), and it down-regulated the transcript abundances of liver-expressed antimicrobial peptide (LEAP)-2A, LEAP-2B, hepcidin, IgZ, IgM and β-defensin1 (except in the PI) (P<0·05); (2) could up-regulate intestinal pro-inflammatory cytokines TNF-α, IL-1β, IL-6, IL-8 and IL-17D mRNA levels partly related to NF-κB signalling; (3) could down-regulate intestinal anti-inflammatory cytokine transforming growth factor (TGF)-β1, TGF-β2, IL-4/13A (not IL-4/13B) and IL-10 mRNA levels partly by target of rapamycin signalling. Finally, on the basis of the specific growth rate, against the enteritis morbidity and IgM contents, the optimum threonine requirements were estimated to be 14·53 g threonine/kg diet (4·48 g threonine/100 g protein), 15.05 g threonine/kg diet (4·64 g threonine/100 g protein) and 15·17 g threonine/kg diet (4·68 g threonine/100 g protein), respectively.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28820083</PMID><DateCompleted><Year>2017</Year><Month>08</Month><Day>25</Day></DateCompleted><DateRevised><Year>2017</Year><Month>08</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1475-2662</ISSN><JournalIssue CitedMedium="Internet"><Volume>118</Volume><Issue>2</Issue><PubDate><Year>2017</Year><Month>Jul</Month></PubDate></JournalIssue><Title>The British journal of nutrition</Title><ISOAbbreviation>Br J Nutr</ISOAbbreviation></Journal><ArticleTitle>Threonine deficiency decreased intestinal immunity and aggravated inflammation associated with NF-κB and target of rapamycin signalling pathways in juvenile grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila.</ArticleTitle><Pagination><MedlinePgn>92-108</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1017/S0007114517001830</ELocationID><Abstract><AbstractText>This study aimed to investigate the impacts of dietary threonine on intestinal immunity and inflammation in juvenile grass carp. Six iso-nitrogenous semi-purified diets containing graded levels of threonine (3·99-21·66 g threonine/kg) were formulated and fed to fishes for 8 weeks, and then challenged with Aeromonas hydrophila for 14 d. Results showed that, compared with optimum threonine supplementation, threonine deficiency (1) decreased the ability of fish against enteritis, intestinal lysozyme activities (except in the distal intestine), acid phosphatase activities, complement 3 (C3) and C4 contents and IgM contents (except in the proximal intestine (PI)), and it down-regulated the transcript abundances of liver-expressed antimicrobial peptide (LEAP)-2A, LEAP-2B, hepcidin, IgZ, IgM and β-defensin1 (except in the PI) (P<0·05); (2) could up-regulate intestinal pro-inflammatory cytokines TNF-α, IL-1β, IL-6, IL-8 and IL-17D mRNA levels partly related to NF-κB signalling; (3) could down-regulate intestinal anti-inflammatory cytokine transforming growth factor (TGF)-β1, TGF-β2, IL-4/13A (not IL-4/13B) and IL-10 mRNA levels partly by target of rapamycin signalling. Finally, on the basis of the specific growth rate, against the enteritis morbidity and IgM contents, the optimum threonine requirements were estimated to be 14·53 g threonine/kg diet (4·48 g threonine/100 g protein), 15.05 g threonine/kg diet (4·64 g threonine/100 g protein) and 15·17 g threonine/kg diet (4·68 g threonine/100 g protein), respectively.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Yu-Wen</ForeName><Initials>YW</Initials><AffiliationInfo><Affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Wei-Dan</ForeName><Initials>WD</Initials><AffiliationInfo><Affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Yang</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Pei</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Jun</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuang</LastName><ForeName>Sheng-Yao</ForeName><Initials>SY</Initials><AffiliationInfo><Affiliation>4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Ling</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Wu-Neng</ForeName><Initials>WN</Initials><AffiliationInfo><Affiliation>4Animal Nutrition Institute,Sichuan Academy of Animal Science,Chengdu 610066,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yong-An</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>5Institute of Hydrobiology,Chinese Academy of Sciences,Wuhan 430072,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Xiao-Qiu</ForeName><Initials>XQ</Initials><AffiliationInfo><Affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>1Animal Nutrition Institute,Sichuan Agricultural University,Chengdu 611130,People's Republic of China.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Nutr</MedlineTA><NlmUniqueID>0372547</NlmUniqueID><ISSNLinking>0007-1145</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D023181">Antimicrobial Cationic Peptides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001798">Blood Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016207">Cytokines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D029941">Fish Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D064451">Hepcidins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007075">Immunoglobulin M</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016328">NF-kappa B</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C475606">liver-expressed antimicrobial peptide 2, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>2ZD004190S</RegistryNumber><NameOfSubstance UI="D013912">Threonine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.7.1.1</RegistryNumber><NameOfSubstance UI="D058570">TOR Serine-Threonine Kinases</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.17</RegistryNumber><NameOfSubstance UI="D009113">Muramidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016980" MajorTopicYN="N">Aeromonas hydrophila</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023181" MajorTopicYN="N">Antimicrobial Cationic Peptides</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001798" MajorTopicYN="N">Blood Proteins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002347" MajorTopicYN="N">Carps</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016207" MajorTopicYN="N">Cytokines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004032" MajorTopicYN="N">Diet</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004751" MajorTopicYN="N">Enteritis</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="N">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005393" MajorTopicYN="N">Fish Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D029941" MajorTopicYN="N">Fish Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016905" MajorTopicYN="N">Gram-Negative Bacterial Infections</DescriptorName><QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D064451" MajorTopicYN="N">Hepcidins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007075" MajorTopicYN="N">Immunoglobulin M</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007422" MajorTopicYN="N">Intestines</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009113" MajorTopicYN="N">Muramidase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016328" MajorTopicYN="N">NF-kappa B</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058570" MajorTopicYN="N">TOR Serine-Threonine Kinases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013912" MajorTopicYN="N">Threonine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName><QualifierName UI="Q000172" MajorTopicYN="Y">deficiency</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N"> 4E-BP1 eIF4E-binding protein 1</Keyword><Keyword MajorTopicYN="N"> ACP acid phosphatase</Keyword><Keyword MajorTopicYN="N"> C complement</Keyword><Keyword MajorTopicYN="N"> DI distal intestine</Keyword><Keyword MajorTopicYN="N"> FE feed efficiency</Keyword><Keyword MajorTopicYN="N"> GOT glutamate-oxaloacetate transaminase</Keyword><Keyword MajorTopicYN="N"> GPT glutamate-puruvate transaminase</Keyword><Keyword MajorTopicYN="N"> IKK IκB kinase</Keyword><Keyword MajorTopicYN="N"> INFγ
interferon γ
</Keyword><Keyword MajorTopicYN="N"> IκBα
inhibitor of κBα
</Keyword><Keyword MajorTopicYN="N"> LA lysozyme activities</Keyword><Keyword MajorTopicYN="N"> LEAP liver-expressed antimicrobial peptide</Keyword><Keyword MajorTopicYN="N"> MI mid intestine</Keyword><Keyword MajorTopicYN="N"> PAC plasma ammonia content</Keyword><Keyword MajorTopicYN="N"> PI proximal intestine</Keyword><Keyword MajorTopicYN="N"> PWG percentage weight gain</Keyword><Keyword MajorTopicYN="N"> S6K1 ribosomal protein S6 kinases 1</Keyword><Keyword MajorTopicYN="N"> SGR special growth rate</Keyword><Keyword MajorTopicYN="N"> TGF transforming growth factor</Keyword><Keyword MajorTopicYN="N"> TOR target of rapamycin</Keyword><Keyword MajorTopicYN="N">Immunity</Keyword><Keyword MajorTopicYN="N">Inflammation</Keyword><Keyword MajorTopicYN="N">Intestine</Keyword><Keyword MajorTopicYN="N">Juvenile grass carp (Ctenopharyngodon idella)</Keyword><Keyword MajorTopicYN="N">NF-κB and target of rapamycin signalling</Keyword><Keyword MajorTopicYN="N">Threonine deficiency</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>8</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2017</Year><Month>8</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28820083</ArticleId><ArticleId IdType="pii">S0007114517001830</ArticleId><ArticleId IdType="doi">10.1017/S0007114517001830</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Dong, Yu Wen" sort="Dong, Yu Wen" uniqKey="Dong Y" first="Yu-Wen" last="Dong">Yu-Wen Dong</name></noRegion><name sortKey="Feng, Lin" sort="Feng, Lin" uniqKey="Feng L" first="Lin" last="Feng">Lin Feng</name><name sortKey="Jiang, Jun" sort="Jiang, Jun" uniqKey="Jiang J" first="Jun" last="Jiang">Jun Jiang</name><name sortKey="Jiang, Wei Dan" sort="Jiang, Wei Dan" uniqKey="Jiang W" first="Wei-Dan" last="Jiang">Wei-Dan Jiang</name><name sortKey="Kuang, Sheng Yao" sort="Kuang, Sheng Yao" uniqKey="Kuang S" first="Sheng-Yao" last="Kuang">Sheng-Yao Kuang</name><name sortKey="Liu, Yang" sort="Liu, Yang" uniqKey="Liu Y" first="Yang" last="Liu">Yang Liu</name><name sortKey="Tang, Ling" sort="Tang, Ling" uniqKey="Tang L" first="Ling" last="Tang">Ling Tang</name><name sortKey="Tang, Wu Neng" sort="Tang, Wu Neng" uniqKey="Tang W" first="Wu-Neng" last="Tang">Wu-Neng Tang</name><name sortKey="Wu, Pei" sort="Wu, Pei" uniqKey="Wu P" first="Pei" last="Wu">Pei Wu</name><name sortKey="Zhang, Yong An" sort="Zhang, Yong An" uniqKey="Zhang Y" first="Yong-An" last="Zhang">Yong-An Zhang</name><name sortKey="Zhou, Xiao Qiu" sort="Zhou, Xiao Qiu" uniqKey="Zhou X" first="Xiao-Qiu" last="Zhou">Xiao-Qiu Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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